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Erved association of CNKSR1 expression and survival outcome suggests scaffolding proteins of the RAS-MAPK pathway may account, in part, for the observed heterogeneity of PDAC biology, and clinically may aid in improved future patient stratification.MethodsStudy participants and tissue microarray (TMA) compositionDe-identified cancer tissues included in this analysis were confirmed to be pancreatic
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32?��?0.06?l?h?1) was significantly higher (t-test, P?=?0.04) and doubled that under a changing environment (0.16?��?0.02?l?h?1, Fig.?3). The range in D over both conditions was significantly different (t-test, P?
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Low CNKSR1 expression (p = 0.3666). Pancreatic tumors with nuclear in addition to cytoplasmic CNKSR1 staining (32/107) showed increased nuclear phospho-ERK expression compared to tumor with cytoplasmic CNKSR1 staining only (p = 0.017). Conclusion: CNKSR1 expression is increased in pancreatic tissue specimens and was found to be an independent prognostic marker of overall survival. CNKSR1 may help
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- mice appear to be rapidly compensated for with the induction of infection, but without a corresponding improvement in clinical status (i.e. survival). This lack of improvement indicates that the direct effects of SP-A on host defense against K. pneumoniae (i.e. enhancement of phagocytosis [12,15] or bacterial killing) may be moreBaselineWT >> SP-A-/WT > SP-A-/SP-A-/- >> WT SP-A-/- > WTFigure 3 N
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Al 10 (Cytokeratin-10) (CK-10) (Keratin-10) Lysozyme 2 Peroxiredoxin 6 Pregnancy zone protein SEC14-like 3 Toll-like receptor 13 precursor Transferrin Accession No. P07724 Q3UCL0 P48036 Q58EV2 P60709 Q80XP1 P06684 P14152 P63260 Q60574 O88844 A2A513 P08905 Q6GT24 Q61838 Q5SQ27 Q6R5N8 Q921I1 WT -3.61 3.05 23.19 -166.30 11.33 5.47 12.19 2.02 0.67 1.80 10.70 24.80 4.36 4.30 5.37 8.92 -4.87 -12.29
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Ecent studies using phosphomimetic mutants of CNKSR1 have identified phosphorylation sites in the scaffold critical for nuclear translocation and activation of MAPK pathway genes [21]. However, to date all CNKSR1 analysis in the context of pancreatic cancer has been performed at a molecular level with no translational or clinically oriented application. Using pancreatic tumor tissues from three in
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They are hoping that in ignorance you will make bets on the Large 6 and 8 rather than the location bets.Gamers mark out figures in all sorts of insane designs like crosses, squares and triangles.