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, PMM RED DEF, RED DEF, RED DEF, RED DEF, RED DEF, RED DEF, RED -193.11 -339.42 -101.12 -132.89 -318.76 -14.69 -6.6 -21.59 21.05 64.33 45.92 48.91 56.63 16.92 -32.60 17.31 19.07 38.47 35.09 15.84 44.05 2.41 132.59 1.41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 5916.11 -43.31 -55.63 28.46 129.29 -14.21 -21.97 -83.18 -54.85 -1.56 -59.43 ND -115.4 -33.59 9.26 27.17 7.7 18.41 8.65 -183.20.63
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Nium Pharmaceuticals, Inc., the manufacturer of TAK733. Acknowledgements This work was funded by The Seaver Institute, the Melanoma Research Foundation, the Melanoma Research Alliance, the Louise Belley and Richard Schnarr Fund, the Wesley Coyle Memorial Fund, the Garcia-Corsini Family Fund, the Keiter Family Foundation and the Caltech-UCLA Joint Center for Translational Medicine (all to A.R.). Au
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Nium Pharmaceuticals, Inc., the manufacturer of TAK733. Acknowledgements This work was funded by The Seaver Institute, the Melanoma Research Foundation, the Melanoma Research Alliance, the Louise Belley and Richard Schnarr Fund, the Wesley Coyle Memorial Fund, the Garcia-Corsini Family Fund, the Keiter Family Foundation and the Caltech-UCLA Joint Center for Translational Medicine (all to A.R.). Au
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Ca, MA) and rested for 24 hours. 0.1 and 1 M of TAK733 or parallel DMSO vehicle control were added in triplicate for 20 hours. Cells were incubated for 1 hour with 2.0 Ci with metabolic tracers chosen as analogues of PET tracers: 3H-DDG (American Radiolabeled Chemicals Inc., St. Louis, MO) in glucose-free RPMI 1640 (Invitrogen), or methyl-3H-thymidine (thymidine, Moravek Biochemicals Inc., Brea, C
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